Report: Tracking system needed to fight fake drugs

WASHINGTON (AP) — Fighting the problem of fake drugs will require putting medications through a chain of custody like U.S. courts require for evidence in a trial, the Institute of Medicine reported Wednesday.

The call for a national drug tracking system comes a week after the Food and Drug Administration warned doctors, for the third time in about a year, that it discovered a counterfeit batch of the cancer drug Avastin that lacked the real tumor-killing ingredient.

Fake and substandard drugs have become an increasing concern as U.S. pharmaceutical companies move more of their manufacturing overseas. The risk made headlines in 2008 when U.S. patients died from a contaminated blood thinner imported from China.

The Institute of Medicine report made clear that this is a global problem that requires an international response, with developing countries especially at risk from phony medications. Drug-resistant tuberculosis, for example, is fueled in part by watered-down medications sold in many poor countries.

"There can be nothing worse than for a patient to take a medication that either doesn't work or poisons the patient," said Lawrence O. Gostin, a professor of health law at Georgetown University who led the IOM committee that studied how to combat the growing problem.

A mandatory drug-tracking system could use some form of barcodes or electronic tags to verify that a medication and the ingredients used to make it are authentic at every step, from the manufacturing of the active ingredient all the way to the pharmacy, he said. His committee examined fakes so sophisticated that health experts couldn't tell the difference between the packaging of the FDA-approved product and the look-alike.

"It's unreliable unless you know where it's been and can secure each point in the supply chain," Gostin said.

Patient safety advocates have pushed for that kind of tracking system for years, but attempts to include it in FDA drug-safety legislation last summer failed.

The report also concluded that:

—The World Health Organization should develop an international code of practice that sets guidelines for monitoring, regulation and law enforcement to crack down on fake drugs.

—States should beef up licensing requirements for the wholesalers and distributors who get a drug from its manufacturer to the pharmacy, hospital or doctor's office.

__Internet pharmacies are a particularly weak link, because fraudulent sites can mimic legitimate ones. The report urged wider promotion of the National Association of Boards of Pharmacy's online accreditation program as a tool to help consumers spot trustworthy sites.

The Institute of Medicine is an independent organization that advises the government on health matters.

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Charred Human Remains Found in Burned Cabin

Investigators have located charred human remains in the burned-out cabin where they believe suspected cop killer and ex-LAPD officer Christopher Dorner was holed up as the structure burned to the ground, police said.

The human remains were found within the debris of the burned cabin and identification will be attempted through forensic means, the San Bernardino County Sheriff-Coroner Department said in a news release early this morning.

Dorner barricaded himself in the cabin in the San Bernardino Mountains near Big Bear Tuesday afternoon after engaging in a gunfight with police, killing one officer and injuring another, the San Bernardino County Sheriff's Department said.

Cindy Bachman, a spokeswoman for the department, which is the lead agency in the action, said Tuesday night investigators would remain at the site all night.

FULL COVERAGE: Christopher Dorner Manhunt

When Bachman was asked whether police thought Dorner was in the burning cabin, she said, "Right. We believe that the person that barricaded himself inside the cabin engaged in gunfire with our deputies and other law enforcement officers is still inside there, even though the building burned."

Bachman spoke shortly after the Los Angeles Police Department denied earlier reports that a body was found in the cabin, contradicting what law enforcement sources told ABC News and other news organizations.

Police around the cabin told ABC News they saw Dorner enter but never leave the building as it was consumed by flames, creating a billowing column of black smoke seen for miles.

A news conference is scheduled for later today in San Bernardino.

One sheriff's deputy was killed in a shootout with Dorner earlier Tuesday afternoon, believed to be his fourth victim after killing a Riverside police officer and two other people this month, including the daughter of a former police captain, and promising to kill many more in an online manifesto.

PHOTOS: Former LAPD Officer Suspected in Shootings

Carjacking Victim Says Christopher Dorner Was Dressed for Damage Watch Video

Christopher Dorner Manhunt: Inside the Shootout Watch Video

Chris Dorner Manhunt: Fugitive Ex-Cop in Shootout With Police Watch Video

Cops said they heard a single gunshot go off from inside the cabin just as they began to see smoke and fire. Later they heard the sound of more gunshots, which was the sound of ammunition being ignited by the heat of the blaze, law enforcement officials said.

Police did not enter the building, but shot tear gas inside.

One of the largest dragnets in recent history, which led police to follow clues across the West and into Mexico, apparently ended just miles from where Dorner's trail went cold last week.

It all began at 12:20 p.m. PT Tuesday, when a maid working at a local resort called 911, saying she and another worker had been tied up and held hostage by Dorner in a cabin, sources said.

The maid told police she was able to escape, but Dorner had stolen one of their cars, which was identified as a purple Nissan.

The San Bernardino Sheriff's Office and state Fish and Wildlife wardens spotted the stolen vehicle and engaged in a shootout with Dorner.

Officials say Dorner crashed the stolen vehicle and fled on foot only to commandeer Rick Heltebrake's white pickup truck on a nearby road a short time later.

"[Dorner] said, 'I don't want to hurt you, just get out and start walking up the road and take your dog with you.' He was calm. I was calm. I would say I was in fear for my life, there was no panic, he told me what to do and I did it," Heltebrake said.

"He was dressed in all camouflage, had a big assault sniper-type rifle. He had a vest on like a ballistic vest," Heltebrake added.

The white pickup truck bought Dorner extra time because police were still looking for the purple Nissan, California Department of Fish and Wildlife Lt. Patrick Foy told "Good Morning America" today.

"We were looking for a purple color Nissan and all of a sudden this white pickup starts coming by in the opposite direction. That's not the suspect's vehicle that we had been looking for," Foy said.

A warden with the Fish and Wildlife department noticed Dorner driving and the pursuit picked up again, Foy said.

"Ultimately, the officer who was driving that vehicle stopped and pulled out his patrol rifle and engaged probably 15 to 20 shots as Dorner was driving away," Foy said.

Dorner then ran on foot to the cabin in which he barricaded himself and got in a shootout with San Bernardino County sheriff's deputies and other officers who arrived.

The two deputies were wounded in the firefight and airlifted to a nearby hospital, where one died, police said. The second deputy was in surgery and was expected to survive, police said.

Police sealed all the roads into the area, preventing cars from entering the area and searching all of those on the way out. All schools were briefly placed on lockdown.

Believing that Dorner might have been watching reports of the standoff, authorities asked media not to broadcast images of police officers' surrounding the cabin, but sent him a message.

"If he's watching this, the message is: Enough is enough," Los Angeles Police Department spokesman Andy Smith told reporters at a news conference Tuesday. "It's time to turn yourself in. It's time to stop the bloodshed. It's time to let this event and let this incident be over."

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China joins U.S., Japan in condemning North Korea nuclear test

SEOUL (Reuters) - North Korea conducted its third nuclear test on Tuesday in defiance of existing U.N. resolutions, drawing condemnation from around the world, including from its only major ally, China, which summoned the North Korean ambassador to protest.

The reclusive North said the test was an act of self-defense against "U.S. hostility" and threatened further, stronger steps if necessary.

It said the test had "greater explosive force" than the 2006 and 2009 tests. Its KCNA news agency said it had used a "miniaturized" and lighter nuclear device, indicating that it had again used plutonium which is more suitable for use as a missile warhead.

North Korean leader Kim Jong-un, the third of his line to rule the country, has presided over two long-range rocket launches and a nuclear test during his first year in power, pursuing policies that have propelled his impoverished and malnourished country closer to becoming a nuclear weapons power.

China, which has shown signs of increasing exasperation with the recent bellicose tone of its neighbor, summoned the North Korean ambassador in Beijing and protested sternly, the Foreign Ministry said.

Foreign Minister Yang Jiechi said China was "strongly dissatisfied and resolutely opposed" to the test and urged North Korea to "stop any rhetoric or acts that could worsen situations and return to the right course of dialogue and consultation as soon as possible".

China is a permanent member of the Security Council.

U.S. President Barack Obama labeled the test a "highly provocative act" that hurt regional stability and pressed for new sanctions.

"The danger posed by North Korea's threatening activities warrants further swift and credible action by the international community. The United States will also continue to take steps necessary to defend ourselves and our allies," Obama said in a statement.

The Security Council will meet on Tuesday to discuss its reaction to the test, although North Korea is already one of the most heavily sanctioned states in the world and has few external economic links that can be targeted.

Japanese Prime Minister Shinzo Abe said the test was a "grave threat" that could not be tolerated. U.N. Secretary-General Ban Ki-moon said the test was a "clear and grave violation" of U.N. Security Council resolutions.

Russian Foreign Minister Sergei Lavrov urged North Korea to abandon its nuclear arms program and return to talks. NATO condemned the test as an "irresponsible act" that posed a grave threat to world peace.

The test "was only the first response we took with maximum restraint", an unnamed spokesman for the North Korean Foreign Ministry, which acts as Pyongyang's official voice to the outside world, said in a statement carried by the official KCNA news agency.

"If the United States continues to come out with hostility and complicates the situation, we will be forced to take stronger, second and third responses in consecutive steps."

North Korea often threatens the United States and its "puppet", South Korea, with destruction in colorful terms.

North Korea told the U.N. disarmament forum in Geneva that it would never bow to resolutions on its nuclear program and that prospects were "gloomy" for the denuclearization of the divided Korean peninsula because of a "hostile" U.S. policy.

South Korea, still technically at war with the North after the 1950-53 civil war ended in a mere truce, also denounced the test.

The magnitude was roughly twice as large as that of 2009, Lassina Zerbo, director of the international data centre division of the Vienna-based Comprehensive Nuclear-Test Ban Treaty Organization, said. The U.S. Geological Survey said that a seismic event measuring 5.1 magnitude had occurred.

"It was confirmed that the nuclear test that was carried out at a high level in a safe and perfect manner using a miniaturized and lighter nuclear device with greater explosive force than previously did not pose any negative impact on the surrounding ecological environment," KCNA said.

Despite China's strong response, the test is likely to be a major embarrassment for Beijing, the North's sole major economic and diplomatic ally.

"The test is hugely insulting to China, which now can be expected to follow through with threats to impose sanctions," said Mark Fitzpatrick of the International Institute for Strategic Studies think tank.

North Korea trumpeted the announcement on its state television channel to patriotic music against the backdrop of an image of its national flag.

It linked the test to its technical prowess in launching a long-range rocket in December, a move that triggered the U.N. sanctions, backed by China, that Pyongyang said prompted it to take Tuesday's action.

The North's ultimate aim, Washington believes, is to design an intercontinental ballistic missile capable of carrying a nuclear warhead that could hit the United States. North Korea says the program is aimed merely at putting satellites in space.

North Korea used plutonium in previous nuclear tests and prior to Tuesday there had been speculation it would use highly enriched uranium so as to conserve its plutonium stocks as testing eats into its limited supply of the material that could be used to construct a nuclear bomb.

"VICIOUS CYCLE"

Despite its three nuclear tests and long-range rocket tests, North Korea is not believed to be close to manufacturing a nuclear missile capable of hitting the United States.

South Korea's Yonhap news agency said Pyongyang had informed China and the United States of its plans to test on Monday, although this could not be confirmed.

When North Korean leader Kim, 30, took power after his father's death in December 2011, there were hopes the he would bring reforms and end Kim Jong-il's "military first" policies.

Instead, the North, whose economy is smaller than it was 20 years ago and where a third of children are believed to be malnourished, appears to be trapped in a cycle of sanctions followed by further provocations.

"The more North Korea shoots missiles, launches satellites or conducts nuclear tests, the more the U.N. Security Council will impose new and more severe sanctions," said Shen Dingli, a professor at Shanghai's Fudan University. "It is an endless, vicious cycle."

But options for the international community appear to be in short supply.

Tuesday's action appeared to have been timed for the run-up to February 16 anniversary celebrations of Kim Jong-il's birthday, as well as to achieved maximum international attention.

Significantly, the test comes at a time of political transition in China, Japan and South Korea, and as Obama begins his second term. He will likely have to tweak his State of the Union address due to be given on Tuesday.

Japanese Prime Minister Shinzo Abe is bedding down a new government and South Korea's new president, Park Geun-hye, prepares to take office on February 25.

China too is in the midst of a once-in-a-decade leadership transition to Xi Jinping, who takes office in March. Both Abe and Xi are staunch nationalists.

The longer-term game plan from Pyongyang may be to restart talks aimed at winning food and financial aid. China urged it to return to the stalled "six-party" talks on its nuclear program, hosted by China and including the two Koreas, the United States, Japan and Russia.

Its puny economy and small diplomatic reach mean the North struggles to win attention on the global stage - other than through nuclear tests and attacks on South Korea, last made in 2010.

"Now the next step for North Korea will be to offer talks... - any form to start up discussion again to bring things to their advantage," said Jeung Young-tae, senior research fellow at the Korea Institute for National Unification in Seoul.

The European Union's foreign policy chief, Catherine Ashton, urged North Korea to refrain from further provocation.

EU member Denmark called on China to step up to the plate and use its influence to rein in its ally.

"This deserves only one thing and that is a one-sided condemnation," said Foreign Minister Villy Sovndal. "North Korea is likely the most horrible country on this planet."

(Additional reporting by Jack Kim, Christine Kim and Jumin Park in SEOUL; Linda Sieg in TOKYO; Louis Charbonneau at the UNITED NATIONS; Fredrik Dahl in VIENNA; Michael Martina and Chen Aizhu in BEIJING; Mette Fraende in COPENHAGEN; Adrian Croft, Charlie Dunmore and Justyna Pawlak in BRUSSELS; Editing by Nick Macfie)

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Horsemeat disguised as beef confirmed in France: company

PARIS: A major French frozen food retailer said on Tuesday it had found horsemeat in two lots of frozen beef lasagne meals it removed from its shelves last week.

Picard, which has hundreds of outlets across France that sell ready-to-eat meals, said the products were made by Comigel, the French firm which last week sparked the frozen food scandal now spreading across Europe.

- AFP

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No merger with anyone, Raj Thackeray responds to Uddhav's offer

MUMBAI: Ruling out merger with the Uddhav Thackeray-led Shiv Sena, Maharashtra Navnirman Sena (MNS) chief Raj Thackeray today said he had no intention of aligning with anybody.

Speaking at a rally in Maharashtra's Kolhapur town, Raj said, "There is no thought now of any alliance. Do talks of alliance happen through newspapers?"

He was making a veiled reference to Uddhav's "merger offer" made through an interview in Sena's mouthpiece 'Saamana' last month.

In the interview, Uddhav Thackeray had said that he would welcome any offer of an alliance between his party and the MNS in the interests of the Marathi people.

Responding to a query on whether the cousins could come together, Uddhav had pointed out, "One cannot clap with a single hand. Tell me, can you?"

Asked what he would do if estranged cousin Raj approached him with a proposal for an alliance, Uddhav had said, "If someone is going to come wholeheartedly with Sena, I will welcome them."

Raj Thackeray split from the Shiv Sena in 2006 after his late uncle Bal Thackeray made it clear that his son Uddhav would succeed him as Sena chief. Last year, Raj had fuelled speculation about a patch-up, visiting his ailing uncle at Matoshree several times.

He also visited Uddhav in hospital when the latter underwent an angiography first, and then an angioplasty.

Raj also attacked migrants from other states, saying they indulge in crimes. "If they indulge in crimes here, teach them a lesson," he told MNS workers.

Raj praised the development work in Gujarat by Narendra Modi. "Why has Maharashtra not been able to emulate the development work in that state," he said.

Alleging that activists close to Maharashtra Home Minister R R Patil were threatening MNS workers and their family members, Raj said that if this does not stop, "We will threaten your (Patil's) family members."

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Pope shows lifetime jobs aren't always for life

The world seems surprised that an 85-year-old globe-trotting pope who just started tweeting wants to resign, but should it be? Maybe what should be surprising is that more leaders his age do not, considering the toll aging takes on bodies and minds amid a culture of constant communication and change.

There may be more behind the story of why Pope Benedict XVI decided to leave a job normally held for life. But the pontiff made it about age. He said the job called for "both strength of mind and body" and said his was deteriorating. He spoke of "today's world, subject to so many rapid changes," implying a difficulty keeping up despite his recent debut on Twitter.

"This seemed to me a very brave, courageous decision," especially because older people often don't recognize their own decline, said Dr. Seth Landefeld, an expert on aging and chairman of medicine at the University of Alabama at Birmingham.

Age has driven many leaders from jobs that used to be for life — Supreme Court justices, monarchs and other heads of state. As lifetimes expand, the woes of old age are catching up with more in seats of power. Some are choosing to step down rather than suffer long declines and disabilities as the pope's last predecessor did.

Since 1955, only one U.S. Supreme Court justice — Chief Justice William Rehnquist — has died in office. Twenty-one others chose to retire, the most recent being John Paul Stevens, who stepped down in 2010 at age 90.

When Thurgood Marshall stepped down in 1991 at the age of 82, citing health reasons, the Supreme Court justice's answer was blunt: "What's wrong with me? I'm old. I'm getting old and falling apart."

One in 5 U.S. senators is 70 or older, and some have retired rather than seek new terms, such as Hawaii's Daniel Akaka, who left office in January at age 88.

The Netherlands' Queen Beatrix, who just turned 75, recently said she will pass the crown to a son and put the country "in the hands of a new generation."

In Germany, where the pope was born, Chancellor Angela Merkel, who is 58, said the pope's decision that he was no longer fit for the job "earns my very highest respect."

"In our time of ever-lengthening life, many people will be able to understand how the pope as well has to deal with the burdens of aging," she told reporters in Berlin.

Experts on aging agreed.

"People's mental capacities in their 80s and 90s aren't what they were in their 40s and 50s. Their short-term memory is often not as good, their ability to think quickly on their feet, to execute decisions is often not as good," Landefeld said. Change is tougher to handle with age, and leaders like popes and presidents face "extraordinary demands that would tax anybody's physical and mental stamina."

Dr. Barbara Messinger-Rapport, geriatrics chief at the Cleveland Clinic, noted that half of people 85 and older in developed countries have some dementia, usually Alzheimer's. Even without such a disease, "it takes longer to make decisions, it takes longer to learn new things," she said.

But that's far from universal, said Dr. Thomas Perls, an expert on aging at Boston University and director of the New England Centenarians Study.

"Usually a man who is entirely healthy in his early 80s has demonstrated his survival prowess" and can live much longer, he said. People of privilege have better odds because they have access to good food and health care, and tend to lead clean lives.

"Even in the 1500s and 1600s there were popes in their 80s. It's remarkable. That would be today's centenarians," Perls said.

Arizona Sen. John McCain turned 71 while running for president in 2007. Had he won, he would have been the oldest person elected to a first term as president. Ronald Reagan was days away from turning 70 when he started his first term as president in 1981; he won re-election in 1984. Vice President Joe Biden just turned 70.

In the U.S. Senate, where seniority is rewarded and revered, South Carolina's Strom Thurmond didn't retire until age 100 in 2002. Sen. Robert Byrd of West Virginia was the longest-serving senator when he died in office at 92 in 2010.

Now the oldest U.S. senator is 89-year-old Frank Lautenberg of New Jersey. The oldest congressman is Ralph Hall of Texas who turns 90 in May.

The legendary Alan Greenspan was about to turn 80 when he retired as chairman of the Federal Reserve in 2006; he still works as a consultant.

Elsewhere around the world, Cuba's Fidel Castro — one of the world's longest serving heads of state — stepped down in 2006 at age 79 due to an intestinal illness that nearly killed him, handing power to his younger brother Raul. But the island is an example of aged leaders pushing on well into their dotage. Raul Castro now is 81 and his two top lieutenants are also octogenarians. Later this month, he is expected to be named to a new, five-year term as president.

Other leaders who are still working:

—England's Queen Elizabeth, 86.

—Abdullah bin Abd al-Aziz al-Saud, king of Saudi Arabia, 88.

—Sabah al-Ahmad al-Jaber al-Sabah, emir of Kuwait, 83.

—Ruth Bader Ginsburg, U.S. Supreme Court associate justice, 79.

__

Associated Press writers Paul Haven in Havana, Cuba; David Rising in Berlin; Seth Borenstein, Mark Sherman and Matt Yancey in Washington, and researcher Judy Ausuebel in New York contributed to this report.

___

Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP

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Fort Hood Hero Says Obama 'Betrayed' Victims

Three years after the White House arranged a hero's welcome at the State of the Union address for the Fort Hood police sergeant and her partner who stopped the deadly shooting there, Kimberly Munley says President Obama broke the promise he made to her that the victims would be well taken care of.

"Betrayed is a good word," former Sgt. Munley told ABC News in a tearful interview to be broadcast tonight on "World News with Diane Sawyer" and "Nightline."

"Not to the least little bit have the victims been taken care of," she said. "In fact they've been neglected."

There was no immediate comment from the White House about Munley's allegations.

Thirteen people were killed, including a pregnant soldier, and 32 others shot in the November 2009 rampage by the accused shooter, Major Nidal Hasan, who now awaits a military trial on charges of premeditated murder and attempted murder.

Tonight's broadcast report also includes dramatic new video, obtained by ABC News, taken in the immediate aftermath of the shooting, capturing the chaos and terror of the day.

WATCH Exclusive Video of Fort Hood's Aftermath

Munley, since laid off from her job with the base's civilian police force, was shot three times as she and her partner, Sgt. Mark Todd, confronted Hasan, who witnesses said had shouted "Allahu Akbar" as he opened fire on soldiers being processed for deployment to Afghanistan.

As Munley lay wounded, Todd fired the five bullets credited with bringing Hasan down.

Charles Dharapak/AP Photo

Leader Wants to Rehabilitate 'Misguided' Youth Watch Video

Despite extensive evidence that Hasan was in communication with al Qaeda leader Anwar al-Awlaki prior to the attack, the military has denied the victims a Purple Heart and is treating the incident as "workplace violence" instead of "combat related" or terrorism.

READ a Federal Report on the FBI's Probe of Hasan's Ties to al-Awlaki

Al-Awlaki has since been killed in a U.S. drone attack in Yemen, in what was termed a major victory in the U.S. efforts against al Qaeda.

Munley and dozens of other victims have now filed a lawsuit against the military alleging the "workplace violence" designation means the Fort Hood victims are receiving lower priority access to medical care as veterans, and a loss of financial benefits available to those who injuries are classified as "combat related."

READ the Fort Hood Victims' Lawsuit

Some of the victims "had to find civilian doctors to get proper medical treatment" and the military has not assigned liaison officers to help them coordinate their recovery, said the group's lawyer, Reed Rubinstein.

"There's a substantial number of very serious, crippling cases of post-traumatic stress disorder exacerbated, frankly, by what the Army and the Defense Department did in this case," said Rubinstein. "We have a couple of cases in which the soldiers' command accused the soldiers of malingering, and would say things to them that Fort Hood really wasn't so bad, it wasn't combat."

A spokesperson for the Army said its policy is not to comment on pending litigation, but that it is "not true" any of the military victims have been neglected and that it has no control over the guidelines of the Veterans Administration.

Secretary of the Army John McHugh told ABC News he was unaware of any specific complaints from the Fort Hood victims, even though he is a named defendant in the lawsuit filed last November which specifically details the plight of many of them.

"If a soldier feels ignored, then we need to know about it on a case by case basis," McHugh told ABC News. "It is not our intent to have two levels of care for people who are wounded by whatever means in uniform."

Some of the victims in the lawsuit believe the Army Secretary and others are purposely ignoring their cases out of political correctness.

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Pope's sudden resignation sends shockwaves through Church

VATICAN CITY (Reuters) - Pope Benedict said in a historic announcement he no longer had the mental and physical strength to run the Roman Catholic Church and would become the first pontiff in more than 700 years to resign, leaving his inner circle "incredulous".

Church officials tried to relay a climate of calm confidence in the running of a 2,000-year-old institution but the decision could lead to one of the most uncertain and unstable periods in centuries for a Church besieged by scandal and defections.

The Church has been rocked during Benedict's nearly eight-year papacy by child sexual abuse crises and Muslim anger after the pope compared Islam to violence. Jews were upset over rehabilitation of a Holocaust denier and there was scandal over the leaking of the pope's private papers by his personal butler.

In the announcement read to cardinals in Latin, the German-born pope, 85, said: "Well aware of the seriousness of this act, with full freedom I declare that I renounce the ministry of Bishop of Rome, Successor of St Peter ...

"As from 28 February 2013, at 20:00 hours (2 p.m. ET) the See of Rome, the See of St. Peter will be vacant and a conclave to elect the new Supreme Pontiff will have to be convoked by those whose competence it is."

The pope, known for his conservative doctrine, did not intend to influence the decision of the cardinals who will enter a secret conclave to elect a successor, Vatican spokesman Father Lombardi Federico said.

Benedict stepped up the Church's opposition to gay marriage, underscored the Church's resistance to a female priesthood and to embryonic stem cell research.

A new leader of the world's 1.2 billion Roman Catholics could be elected as soon as Palm Sunday, on March 24 and be ready to take over by Easter a week later, he said.

EX-POPE AND REIGNING POPE

Lombardi said the pope did not fear a possible "schism" but several popes in the past, including Benedict's predecessor John Paul, refrained from stepping down precisely because of the confusion and division that could be caused by having an "ex-pope" and a reigning pope living at the same time.

This could create a particularly difficult problem if the next pope is a progressive who influences such teachings as the ban on women priests and artificial birth control and its insistence on a celibate priesthood.

"This is disconcerting, he is leaving his flock," said Alessandra Mussolini, a parliamentarian who is granddaughter of Italy's wartime dictator.

"The pope is not any man. He is the vicar of Christ. He should stay on to the end, go ahead and bear his cross to the end. This is a huge sign of world destabilization that will weaken the Church."

The pope's elder brother Georg Ratzinger, a frail 89-year-old priest who shares the pope's passion for music, told reporters in the Bavarian town of Regensburg where he once conducted the cathedral choir that he had been "very surprised" to learn of his brother's resignation.

"He alone can evaluate his physical and emotional strength," said Ratzinger.

Lombardi said Benedict would first go to the papal summer residence south of Rome and then move into a cloistered convent inside the Vatican walls. It was not clear if Benedict would have a public life.

The last Pope to resign willingly was Celestine V in 1294 after reigning for only five months, his resignation was known as "the great refusal" and was condemned by the poet Dante in the "Divine Comedy". Gregory XII reluctantly abdicated in 1415 to end a dispute with a rival claimant to the papacy.

NO SPECIFIC ILLNESS, NO DEPRESSION

Lombardi said Benedict's decision showed "great courage". He ruled out any specific illness or depression and said the decision was made in the last few months "without outside pressure".

While the pope had slowed down recently - he started using a cane and a wheeled platform to take him up the long aisle in St Peter's Square - he had given no hint recently that he was mulling such a dramatic decision.

"I am really surprised," said Ricardo Rodriguez, a Portuguese tourist in St Peter's Square. "I hope the next pope can be better than this one doing the best for the world and Catholics," he said.

Elected in 2005 to succeed the enormously popular John Paul, Benedict never appeared to feel comfortable in a job he said he never wanted. He had wanted to retire to his native Germany to pursue his theological writings, something which he will now do from a convent inside the Vatican.

The resignation means that cardinals from around the world will begin arriving in Rome in March and after preliminary meetings, lock themselves in a secret conclave.

There has been growing pressure on the Church for the cardinals to shun European contenders and choose a pope from the developing world in order to better reflect parts of the globe where most Catholics live and where the Church is growing.

"MIND AND BODY"

The pope told the cardinals that in order to govern "...both strength of mind and body are necessary, strength which in the last few months, has deteriorated in me to the extent that I have had to recognize my incapacity to adequately fulfill the ministry entrusted to me."

He referred to "today's world, subject to so many rapid changes and shaken by questions of deep relevance for the life of faith".

Before he was elected pope, the former Cardinal Joseph Ratzinger, was known by such critical epithets as "God's rottweiler" because of his stern stand on theological issues.

After a few months, he showed his mild side but he never drew the kind of adulation that had marked the 27-year papacy of his predecessor John Paul.

The Archbishop of Canterbury, leader of the worldwide Anglican communion at odds with the Vatican over women priests, said he had learned of the pope's decision with a heavy heart but complete understanding.

German Chancellor Angela Merkel said the pope's decision must be respected if he feels he is too weak to carry out his duties. British Prime Minister David Cameron said: "He will be missed as a spiritual leader to millions."

Elected to the papacy on April 19, 2005 when he was 78 - 20 years older than John Paul was when he was elected - Benedict ruled over a slower-paced, more cerebral and less impulsive Vatican.

CHEERS AND SCANDAL

But while conservatives cheered him for trying to reaffirm traditional Catholic identity, his critics accused him of turning back the clock on reforms by nearly half a century and hurting dialogue with Muslims, Jews and other Christians.

Under the German's meek demeanor lay a steely intellect ready to dissect theological works for their dogmatic purity and debate fiercely against dissenters.

After appearing uncomfortable in the limelight at the start, he began feeling at home with his new job and showed that he intended to be pope in his way.

Despite great reverence for his charismatic, globe-trotting predecessor -- whom he put on the fast track to sainthood and whom he beatified in 2011 -- aides said he was determined not to change his quiet manner to imitate John Paul's style.

A quiet, professorial type who relaxed by playing the piano, he managed to show the world the gentle side of the man who was the Vatican's chief doctrinal enforcer for nearly a quarter of a century.

The first German pope for some 1,000 years and the second non-Italian in a row, he travelled regularly, making about four foreign trips a year, but never managed to draw the oceanic crowds of his predecessor.

The child abuse scandals hounded most of his papacy. He ordered an official inquiry into abuse in Ireland, which led to the resignation of several bishops.

Scandal from a source much closer to home hit in 2012 when the pontiff's butler, responsible for dressing him and bringing him meals, was found to be the source of leaked documents alleging corruption in the Vatican's business dealings, causing an international furor.

Benedict confronted his own country's past when he visited the Nazi death camp at Auschwitz.

Calling himself "a son of Germany", he prayed and asked why God was silent when 1.5 million victims, most of them Jews, died there during World War Two.

Ratzinger served in the Hitler Youth during World War Two when membership was compulsory. He was never a member of the Nazi party and his family opposed Adolf Hitler's regime.

(Philip Pullella; editing by Peter Millership, Ralph Boulton, Janet McBride)

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US tornadoes strike southern states, 60 injured

MIAMI: Several powerful tornadoes ripped through the southern US states of Mississippi and Alabama injuring at least 60 people and destroying hundreds of homes at the weekend, emergency officials said Monday.

The city of Hattiesburg in Mississippi's Forrest County bore the brunt of the storms, with heavy rain continuing to lash the region and create a risk of flooding.

"Two people were critically hurt in Lemar County right next to Hattiesburg, but no deaths have been reported at this stage," Greg Flynn, a spokesman for the Mississippi Emergency Management Agency (MEMA), told AFP.

"Around 60 people are reported injured, but fortunately most injuries are minor," he said.

The bad weather, however, destroyed hundreds of homes and caused damage to the campus of the University of Southern Mississippi, authorities said.

A spokeswoman for the Alabama Emergency Management Agency (AEMA) said that while the area was hit by bad weather on Sunday it had so far received no reports of injuries.

The National Weather Service said flooding and flash flooding will become a concern if rainfall continues to add up across the lower Mississippi valley.

-AFP/ac

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Suspend, book cops who 'detained' Gilani: Katju

NEW DELHI: Slamming the police for "detaining" journalist Iftikhar Gilani on Sunday, Press Council of India chairman Markanday Katju on Monday asked Union home secretary to charge and suspend the cops if the allegations of "high-handedness" against them were correct.

In a letter to the home secretary RK Singh , Justice Katju also sought immediate institution of criminal proceedings against such officers under relevant provisions of IPC and grant of compensation and apology to Gilani for his alleged harassment.

He said the action against the cops should be initiated by the government within 48 hours.

The letter came after Gilani in an email to Katju complained that security agencies had illegally detained him on Sunday at the house of his father-in-law Syed Ali Geelani following the hanging of Parliament attack convict Afzal Guru and harassed him for many hours.

Syed Ali Shah Geelani is a Kashmiri separatist leader who heads the hardline faction of Hurriyat Conference.

Katju used the opportunity to ask police personnel to not carry out such "illegal" orders of their superiors, "otherwise they will be charged for serious crimes, and if found guilty, severely punished".

On Gilani's charges of harassment, Katju said, "They reveal great high-handedness and outrageous behaviour by the Delhi policemen concerned in harassing and tormenting Mr Gilani and his family, including his small children. These were the undemocratic and abhorrent methods of the Gestapo during Nazi rule.

The PCI chairman said, "If these allegations are correct, the concerned police officers ... as well as those higher ups who were instrumental in ordering these shameful and odious acts are prime facie guilty of serious crimes."

Katju said the incident was a "clear violation" of the Supreme Court directions.

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