Retooling Pap test to spot more kinds of cancer

WASHINGTON (AP) — For years, doctors have lamented that there's no Pap test for deadly ovarian cancer. Wednesday, scientists reported encouraging signs that one day, there might be.

Researchers are trying to retool the Pap, a test for cervical cancer that millions of women get, so that it could spot early signs of other gynecologic cancers, too.

How? It turns out that cells can flake off of tumors in the ovaries or the lining of the uterus, and float down to rest in the cervix, where Pap tests are performed. These cells are too rare to recognize under the microscope. But researchers from Johns Hopkins University used some sophisticated DNA testing on the Pap samples to uncover the evidence — gene mutations that show cancer is present.

In a pilot study, they analyzed Pap smears from 46 women who already were diagnosed with either ovarian or endometrial cancer. The new technique found all the endometrial cancers and 41 percent of the ovarian tumors, the team reported Wednesday in the journal Science Translational Medicine.

This is very early-stage research, and women shouldn't expect any change in their routine Paps. It will take years of additional testing to prove if the so-called PapGene technique really could work as a screening tool, used to spot cancer in women who thought they were healthy.

"Now the hard work begins," said Hopkins oncologist Dr. Luis Diaz, whose team is collecting hundreds of additional Pap samples for more study and is exploring ways to enhance the detection of ovarian cancer.

But if it ultimately pans out, "the neat part about this is, the patient won't feel anything different," and the Pap wouldn't be performed differently, Diaz added. The extra work would come in a lab.

The gene-based technique marks a new approach toward cancer screening, and specialists are watching closely.

"This is very encouraging, and it shows great potential," said American Cancer Society genetics expert Michael Melner.

"We are a long way from being able to see any impact on our patients," cautioned Dr. Shannon Westin of the University of Texas MD Anderson Cancer Center. She reviewed the research in an accompanying editorial, and said the ovarian cancer detection would need improvement if the test is to work.

But she noted that ovarian cancer has poor survival rates because it's rarely caught early. "If this screening test could identify ovarian cancer at an early stage, there would be a profound impact on patient outcomes and mortality," Westin said.

More than 22,000 U.S. women are diagnosed with ovarian cancer each year, and more than 15,000 die. Symptoms such as pain and bloating seldom are obvious until the cancer is more advanced, and numerous attempts at screening tests have failed.

Endometrial cancer affects about 47,000 women a year, and kills about 8,000. There is no screening test for it either, but most women are diagnosed early because of postmenopausal bleeding.

The Hopkins research piggybacks on one of the most successful cancer screening tools, the Pap, and a newer technology used along with it. With a standard Pap, a little brush scrapes off cells from the cervix, which are stored in a vial to examine for signs of cervical cancer. Today, many women's Paps undergo an additional DNA-based test to see if they harbor the HPV virus, which can spur cervical cancer.

So the Hopkins team, funded largely by cancer advocacy groups, decided to look for DNA evidence of other gynecologic tumors. It developed a method to rapidly screen the Pap samples for those mutations using standard genetics equipment that Diaz said wouldn't add much to the cost of a Pap-plus-HPV test. He said the technique could detect both early-stage and more advanced tumors. Importantly, tests of Paps from 14 healthy women turned up no false alarms.

The endometrial cancers may have been easier to find because cells from those tumors don't have as far to travel as ovarian cancer cells, Diaz said. Researchers will study whether inserting the Pap brush deeper, testing during different times of the menstrual cycle, or other factors might improve detection of ovarian cancer.

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Whales Trapped Under Sea Ice Free Themselves

The killer whales trapped under ice in a remote Quebec village reached safety after the floes shifted on Hudson Bay, according to the mayor's office in Inukjuak.

Water opened up around the area where the orcas had been coming up for air and the winds seemed to have shifted overnight, creating a passageway to the open water six miles away.

"This is great news," Johnny Williams, a resident who works for the mayor's office, told ABC News.

Williams said he was unsure how far the whales have moved, but that they were definitely not under the ice hole.

Residents in the remote village of Inukjuak had been watching helplessly as at least 12 whales struggled to breathe out of a hole slightly bigger than a pickup truck in a desperate bid to survive.

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The community had asked the Canadian government for help in freeing the killer whales, believed to be an entire family. The government denied a request to bring icebreakers Wednesday, saying they were too far away to help. Inukjuak, about 900 miles north of Montreal, was ill-equipped to jump into action.

Joe Gaydos, director and chief scientist at the SeaDoc Society in Eastsound, Wash., said that although the whales can go a long time without food, the length of time they can hold their breath, which they must do underwater, was the question.

"The challenge [was] to figure out where the next hole is," he told ABCNews.com before the whales found freedom. "If that lake freezes over, it's an unfortunate situation. It's a very limited chance. It's a matter of luck."

Inukjuak residents posted a video online to show the whales' struggles. In the clip, the whales are seen taking turns breathing. They can't bend their necks so they do a "spy-hopping" maneuver, Gaydos said, in order to look for another hole in the ice.

A hunter first spotted the pod of trapped whales Tuesday. It is believed that the whales swam into the waters north of Quebec during recent warm weather.

ABC News' Bethany Owings contributed to this report

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Freed Iranians arrive in Damascus after prisoner swap

DAMASCUS/ISTANBUL (Reuters) - Forty-eight Iranians freed by Syrian rebels in exchange for more than 2,000 civilian prisoners held by the Syrian government arrived in central Damascus on Wednesday, a Reuters witness reported.

The Syrian government has not referred to the prisoner swap and the whereabouts of the civilian prisoners was not immediately known.

Opposition groups accuse it of detaining tens of thousands of political prisoners during his 12 years in office and say those numbers have spiked sharply during the 21-month-old civil war.

The Syrian rebel al-Baraa brigade seized the Iranians in early August and initially threatened to kill them, saying they were members of Iran's elite Islamic Revolutionary Guard Corps sent to fight for President Bashar al-Assad.

The Islamic Republic, one of his staunchest allies, denied this, saying they were Shi'ite Muslim pilgrims visiting shrines, and it asked Turkey and Qatar to use their connections with Syrian insurgents to help secure their release.

The freed Iranians arrived at a Damascus hotel in six small buses, looking tired but in good health, each carrying a white flower, and they were welcomed by Iranian Ambassador Mohammad Reza Sheibani. They did not speak to reporters.

Bulent Yildirim, head of the Turkish humanitarian aid agency IHH which helped broker the deal, told Reuters by telephone from Damascus shortly beforehand that the reciprocal release of 2,130 civilian prisoners - most of them Syrian but also including Turks and other foreign citizens - had begun.

Syrian government forces have struck local deals with rebel groups to trade prisoners but the release announced on Wednesday was the first time non-Syrians were freed in an exchange.

The Damascus government has periodically freed hundreds of prisoners during the conflict but always stressed such detainees "do not have blood on their hands."

Given the number of political prisoners held during the course of Assad's rule, missing persons became a key issue when street protests against him first erupted in March 2011.

Turkey is one of Assad's fiercest critics, a strong backer of his opponents and proponent of international intervention. It has denounced Iran's stance during the Syrian uprising, which has killed around 60,000 people according to a U.N. estimate.

Turkey, Gulf Arab states, the United States and European allies support the mainly Sunni Muslim Syrian rebels, while Shi'ite Iran supports Assad, whose Alawite minority is an offshoot of Shi'ite Islam.

A pro-government newspaper said on December 31 that Syrian forces arrested four Turkish fighter pilots who were trying to sneak into a military airport with an armed group in the northern province of Aleppo.

The Damascus-based al-Watan newspaper said the arrests at the Koers military base, 24 km (15 miles) east of Aleppo city, proved "scandalous Turkish involvement" in Syria's crisis.

TURKEY, QATAR INTERVENE

The al-Baraa brigade, part of the umbrella rebel organization, the Free Syrian Army, said in October it would start killing the Iranians unless Assad freed Syrian opposition detainees and stopped shelling civilian areas.

But Qatar, following a request from Iran, urged the rebels not to carry out the threat.

Insurgents fighting to topple Assad accuse Iran of sending fighters from the Revolutionary Guards to help his forces crush the revolt, a charge the Islamic Republic denies.

The rebels now control wide areas of northern and eastern Syria, most of its border crossings with Turkey and a crescent of suburbs around the capital Damascus.

But Assad's government is still firmly entrenched in the capital and controls most of the densely populated southwest, the Mediterranean coast and the main north-south highway.

The IHH has been involved in previous negotiations in recent months to release prisoners, including two Turkish journalists and Syrian citizens, held in Syria.

The humanitarian group came to prominence in May 2010 when Israeli marines stormed its Mavi Marmara aid ship to enforce a naval blockade of the Palestinian-run Gaza Strip and killed nine Turks in clashes with activists on board.

(Additional reporting by Oliver Holmes in Beirut and Marcus George in Dubai; Writing by Nick Tattersall)

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Hong Kong leader survives impeachment bid

HONG KONG: Hong Kong pro-democracy lawmakers failed in an unprecedented bid on Wednesday to impeach the city's embattled Beijing-backed leader, after they accused him of breaking housing laws and urged him to quit.

The city's first impeachment motion, which accused Leung Chun-ying of lying, dereliction of duty and serious breaches of the law in a row stemming from illegal structures at his luxury home, was denied after eight hours of debate.

The 27 pro-democracy lawmakers who signed the joint motion -- which they said was a symbolic move -- voted in favour, while 37 voted against in the 70-seat legislature which is dominated by pro-Beijing members.

Wednesday's vote followed a protest on New Year's Day in which tens of thousands took to the streets to urge Leung to quit and to press for greater democracy, 15 years after the city returned to Chinese rule.

The former British colony maintains a semi-autonomous status, with its own legal and judicial system, but cannot choose its leader through the popular vote.

Leung took office in July after he was picked by a 1,200-strong election committee dominated by pro-Beijing elites, amid rising anger over what many perceive to be China's meddling in local affairs.

China has said the chief executive could be directly elected in 2017 at the earliest, with the legislature following by 2020.

Unauthorised structures are a politically sensitive issue in the space-starved city of seven million and demonstrators have used the scandal to press for universal suffrage in choosing Hong Kong's leader.

Leung secured the chief executive role after criticising his rival Henry Tang over illegal structures at Tang's home.

But he has since acknowledged and apologised for structures at his own home which were built without planning permission.

Maverick lawmaker "Long Hair" Leung Kwok-hung, wearing a T-shirt reading "We topple a tyrant", accused the new leader of lying about his own structures during campaigning when he presented the impeachment motion earlier on Wednesday.

"He has used dishonest ways to win the election," he said.

Chief Secretary Carrie Lam, second in command in Leung's administration, said the motion was unnecessary and urged lawmakers to work together on policy and livelihood issues.

But Democratic Party chairwoman Emily Lau said the motion was a symbolic gesture to show the deepening public mistrust toward Leung, claiming the leader had "cheated his way to power".

"This is the first time we have a motion in the legislature to impeach a cheating chief executive," she said.

If the motion had been passed, the city's highest court would have had to initiate an investigation. At least two-thirds of the legislature would need to endorse a guilty finding before Leung could be removed from office.

Earlier, rival protesters traded barbs outside the legislature and security personnel had to step in at one point when an angry pro-government supporter charged towards the rival group, TV footage showed.

Leung's popularity ratings have fallen since the controversy, with discontent over issues including sky-high property prices and anti-Beijing sentiment remaining high.

- AFP/xq

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Visa-on-arrival for Pak nationals above 65 years from January 15

ATTARI: The visa-on-arrival facility at the Attari-Wagah check post to Pakistani nationals over 65 years of age will begin from January 15, but they would not be able to stay in Punjab, Kerala and Jammu & Kashmir.

"From January 15, people from Pakistan above 65 years of age can avail the visa-on-arrival on reaching the Attari Integrated Check Post (ICP)," a government official said.

"It has been decided not to give visa-on-arrival for stay in Punjab, Jammu & Kashmir, Kerala, besides restrictive and prohibitive regions. Amritsar will only be used as transit point," the official added.

Under the liberalised visa regime, parts of which were operationalised during the visit of Pakistan interior minister Rehman Malik to New Delhi on December 14, senior citizens above 65 years can visit twice a year and can go to five places in the country. However, there has to be a gap of two months between the two visits.

Both the countries are likely to start this arrangement simultaneously at the Attari-Wagah check-post.

The official said that visa, which would be granted to people in the prescribed age group crossing the border on foot, would be given for maximum of 45 days of stay in one visit and the visa fee would be Rs 100 or two US dollars.

In September 2012, the then external affairs minister S M Krishna and Malik signed a pact liberalising the restrictive visa agreement between India and Pakistan.

At present, nearly 100 person use Attari Wagah check post daily to cross border on foot with a good number of senior citizens. The new system is being introduced to facilitate senior citizens who mostly come for treatment or reunion with relatives in India. Now with the new mechanism, the number is likely to increase, the official said.

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Flu season has Boston declaring health emergency

BOSTON (AP) — Massachusetts public health officials are reporting 18 flu-related deaths in the state already this season, and Boston has declared a public health emergency.

A spokeswoman for Mayor Thomas Menino says the city is working with health care centers to offer free flu vaccines and also hopes to set up public locations where people can go for vaccinations. The city is reporting four flu-related deaths.

There have been about 700 confirmed cases of the flu in Boston so far this season, about 10 times more than in the same period last year.

The Massachusetts Department of Public Health says the state is one of many reporting above average flu hospitalization rates. The Centers for Disease Control and Prevention has warned of a harsh flu season, which usually peaks in midwinter.

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Hospitals Flooded With Flu Patients

U.S. emergency rooms have been overwhelmed with flu patients, turning away some of them and others with non-life-threatening conditions for lack of space.

Forty-one states are battling widespread influenza outbreaks, including Illinois, where six people -- all older than 50 -- have died, according to the state's Department of Public Health.

At least 18 children in the country have died during this flu season, according to the U.S. Centers for Disease Control and Prevention.

The proportion of people seeing their doctor for flu-like symptoms jumped to 5.6 percent from 2.8 percent in the past month, according to the CDC.

Northwestern Memorial Hospital in Chicago reported a 20 percent increase in flu patients every day. Northwestern Memorial was one of eight hospitals on bypass Monday and Tuesday, meaning it asked ambulances to take patients elsewhere if they could do so safely.

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Most of the hospitals have resumed normal operations, but could return to the bypass status if the influx of patients becomes too great.

"Northwestern Memorial Hospital is an extraordinarily busy hospital, and oftentimes during our busier months, in the summer, we will sometimes have to go on bypass," Northwestern Memorial's Dr. David Zich said. "We don't like it, the community doesn't like it, but sometimes it is necessary."

A tent outside Lehigh Valley Hospital in Salisbury Township, Pa., was set up to tend to the overflowing number of flu cases.

A hospital in Ohio is requiring patients with the flu to wear masks to protect those who are not infected.

State health officials in Indiana have reported seven deaths. Five of the deaths occurred in people older than 65 and two younger than 18. The state will release another report later today.

Doctors are especially concerned about the elderly and children, where the flu can be deadly.

"Our office in the last two weeks has exploded with children," Dr. Gayle Smith, a pediatrician in Richmond, Va., said

It is the earliest flu season in a decade and, ABC News Chief Medical Editor Dr. Besser says, it's not too late to protect yourself from the outbreak.

"You have to think about an anti-viral, especially if you're elderly, a young child, a pregnant woman," Besser said.

"They're the people that are going to die from this. Tens of thousands of people die in a bad flu season. We're not taking it serious enough."

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Tunisia frees man held over attack on U.S. consulate in Libya

Tunis (Reuters) - Tunisia has freed, for lack of evidence, a Tunisian man who had been suspected of involvement in an Islamist militant attack in Libya last year in which the U.S. ambassador was killed, his lawyer said on Tuesday.

Ali Harzi was one of two Tunisians named in October by the Daily Beast website as having been detained in Turkey over the violence in which Christopher Stevens, the U.S. ambassador to Libya, and three other American officials were killed.

"The judge decided to free Harzi and he is free now," lawyer Anouar Awled Ali told Reuters. "The release came in response to our request to free him for lack of evidence and after he underwent the hearing with American investigators as a witness in the case."

A Tunisian justice ministry spokesman confirmed the release of Harzi but declined to elaborate.

A month ago, Harzi refused to be interviewed by visiting U.S. FBI investigators over the September 11 assault on the U.S. consulate in the eastern Libyan city of Benghazi.

The Daily Beast reported that shortly after the attacks began, Harzi posted an update on an unspecified social media site about the fighting.

It said Harzi was on his way to Syria when he was detained in Turkey at the behest of U.S. authorities, and that he was affiliated with a militant group in North Africa.

(Reporting by Tarek Amara; Editing by Mark Heinrich)

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India says two soldiers killed in clash with Pakistan troops

SRINAGAR, India: Pakistani troops killed two Indian soldiers on Tuesday near the tense disputed border between the nuclear-armed neighbours in Kashmir and one of the bodies was badly mutilated, the Indian army said.

The firefight broke out at about noon on Tuesday (0630 GMT) after an Indian patrol discovered Pakistani troops about half a kilometre (1,600 feet) inside Indian territory, an army spokesman told AFP.

A ceasefire has been in place along the Line of Control that divides the countries since 2003, but it is periodically violated by both sides and Pakistan said Indian troops killed a Pakistani soldier on Sunday.

Relations had been slowly improving over the last few years following a rupture in their slow-moving peace process after the 2008 attacks on Mumbai, which were blamed by India on Pakistan-based militants.

"There was a firefight with Pakistani troops," army spokesman Rajesh Kalia told AFP from the mountainous Himalayan region.

"We lost two soldiers and one of them has been badly mutilated," he added, declining to give more details on the injuries.

"The intruders were regular (Pakistani) soldiers and they were 400-500 metres (1,300-1,600 feet) inside our territory," he said of the clash in Mendhar sector, 173 kilometres (107 miles) west by road from the city of Jammu.

In Islamabad, a Pakistan military spokesman denied what he called an "Indian allegation of unprovoked firing". He declined to elaborate.

On Sunday, Pakistan said Indian troops had crossed the Line of Control and stormed a military post. It said one Pakistani soldier was killed and another injured.

It lodged a formal protest with India on Monday over what it called an unprovoked attack.

India denied crossing the line, saying it had retaliated with small arms fire after Pakistani mortars hit a village home.

A foreign ministry spokesman said Indian troops had undertaken "controlled retaliation" on Sunday after "unprovoked firing" which damaged a civilian home.

The deaths are set to undermine recent efforts to improve relations, such as opening up trade and offering more lenient visa regimes which have been a feature of talks between senior political leaders from both sides.

Muslim-majority Kashmir is a Himalayan region which India and Pakistan both claim in full but rule in part. It was the cause of two of three wars between the neighbours since independence from Britain in 1947.

- AFP/fa

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India to respond to 'ghastly' attack on troops: Salman Khurshid

NEW DELHI: Foreign minister Salman Khurshid said on Tuesday that New Delhi would give a "proportionate" response to the "ghastly" death of two soldiers at the hands of Pakistani troops along the Line of Control.

"We need to do something about this and we will, but it has to be done after careful consideration of all the details in consultation with the defence ministry," Salman Khurshid said in an interview to a news channel.

"It is absolutely unacceptable, ghastly, and really, really terrible and extremely short-sighted by their part," he added, saying any response would be "proportionate".

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